The 3F Library: Fluorinated Fsp 3 ‐Rich Fragments for Expeditious 19 F NMR Based Screening
نویسندگان
چکیده
منابع مشابه
Applications of (19)F-NMR in Fragment-Based Drug Discovery.
(19)F-NMR has proved to be a valuable tool in fragment-based drug discovery. Its applications include screening libraries of fluorinated fragments, assessing competition among elaborated fragments and identifying the binding poses of promising hits. By observing fluorine in both the ligand and the target protein, useful information can be obtained on not only the binding pose but also the dynam...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2019
ISSN: 0044-8249,1521-3757
DOI: 10.1002/ange.201913125